CD4(+) memory T cell survival.
, Jenkins MK
Department of Microbiology and the Center for Immunology, University of Minnesota, 2101 Sixth St. SE, Minneapolis, MN 55455, United States.
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Memory CD4(+) T cells specific for a given antigen are generated during the primary response from the effector lymphoblast progeny of naïve precursors. How memory CD4(+) T cells differentiate from the effector population is not understood but new tools to assess transcription factor and cytokine expression are allowing for a more careful assessment of this process. Here we review the factors that allow some effector CD4(+) T cells to survive the contraction phase of the primary response and become memory cells, and consider whether parallels can be drawn between T and B cells.
PMID: 21524898 [PubMed - as supplied by publisher]