絞り込み

16645

広告

PHF6 mutations in adult acute myeloid leukemia.

著者 Van Vlierberghe P , Patel J , Abdel-Wahab O , Lobry C , Hedvat CV , Balbin M , Nicolas C , Payer AR , Fernandez HF , Tallman MS , Paietta E , Melnick A , Vandenberghe P , Speleman F , Aifantis I , Cools J , Levine R , Ferrando A
Leukemia.2010 Oct 29 ; ():.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

[1] Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA [2] Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium.

スターを付ける スターを付ける     (51view , 0users)
Loss of function mutations and deletions encompassing the plant homeodomain finger 6 (PHF6) gene are present in about 20% of T-cell acute lymphoblastic leukemias (ALLs). Here, we report the identification of recurrent mutations in PHF6 in 10/353 adult acute myeloid leukemias (AMLs). Genetic lesions in PHF6 found in AMLs are frameshift and nonsense mutations distributed through the gene or point mutations involving the second plant homeodomain (PHD)-like domain of the protein. As in the case of T-ALL, where PHF6 alterations are found almost exclusively in males, mutations in PHF6 were seven times more prevalent in males than in females with AML. Overall, these results identify PHF6 as a tumor suppressor gene mutated in AML and extend the role of this X-linked tumor suppressor gene in the pathogenesis of hematologic tumors.Leukemia advance online publication, 29 October 2010; doi:10.1038/leu.2010.247.
PMID: 21030981 [PubMed - as supplied by publisher]
印刷用ページを開く Endnote用テキストダウンロード