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MG53 constitutes a primary determinant of cardiac ischemic preconditioning.

著者 Cao CM , Zhang Y , Weisleder N , Ferrante C , Wang X , Lv F , Zhang Y , Song R , Hwang M , Jin L , Guo J , Peng W , Li G , Nishi M , Takeshima H , Ma J , Xiao RP
Circulation.2010 Jun 15 ; 121(23):2565-74.
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Ischemic heart disease is the greatest cause of death in Western countries. The deleterious effects of cardiac ischemia are ameliorated by ischemic preconditioning (IPC), in which transient ischemia protects against subsequent severe ischemia/reperfusion injury. IPC activates multiple signaling pathways, including the reperfusion injury salvage kinase pathway (mainly PI3K-Akt-glycogen synthase kinase-3beta [GSK3beta] and ERK1/2) and the survivor activating factor enhancement pathway involving activation of the JAK-STAT3 axis. Nevertheless, the fundamental mechanism underlying IPC is poorly understood.
PMID: 20516375 [PubMed - indexed for MEDLINE]
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