With a little help from their friends: interleukin-21, T cells, and B cells.
, Hunter CA
Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Room 313, Hill Pavillion, 380 South University Avenue, Philadelphia, PA 19104-4539, USA.
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T follicular cells help B cells generate high-affinity antibodies. Two papers in this issue of Immunity (Nurieva et al., 2008, and Vogelzang et al., 2008) have identified a role for interleukin-21 in the development of these specialized cells and highlight questions about how this dedicated population is generated.
PMID: 18631451 [PubMed - indexed for MEDLINE]