絞り込み

16646

広告

「震災の影響確認して判断した」 (デイリースポーツ)

東北電力が再稼働を目指す女川原発2号機(宮城県)が原子力規制委員会の審査に合格したことを受け、規制委の更田豊志委員長は26日の記者会見で「東日本大震災の影響をき...

  1. 東京、京都など4つの国立博物館 あすから...
  2. 米国で新型コロナウイルスに対する世界初の...
  3. 国立がん研究センターなどが日本人肺腺癌の...
  4. 横浜港で検疫中のクルーズ船内で確認された...

ニュース一覧

Melanocortin-4 receptor activation stimulates hypothalamic brain-derived neurotrophic factor release to regulate food intake, body temperature and cardiovascular function.

著者 Nicholson JR , Peter JC , Lecourt AC , Barde YA , Hofbauer KG
J Neuroendocrinol.2007 Dec ; 19(12):974-82.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Applied Pharmacology, University of Basel, Basel, Switzerland.

スターを付ける スターを付ける     (18view , 0users)

Full Text Sources

Other Literature Sources

In the present study, we aimed to investigate the neuromodulatory role played by hypothalamic brain-derived neurotrophic factor (BDNF) in the regulation of acute cardiovascular and feeding responses to melanocortin-4 receptor (MC4R) activation. In vitro, a selective MC4R agonist, MK1, stimulated BDNF release from isolated rat hypothalami and this effect was blocked by preincubation with the MC3/4R antagonist SHU-9119. In vivo, peripheral administration of MK1 decreased food intake in rats and this effect was blocked by pretreatment with an anti-BDNF antibody administered into the third ventricle. When anorexia was induced with the cannabinoid-1 receptor (CB1R) antagonist AM251, the anti-BDNF antibody did not prevent the reduction in food intake. Peripheral administration of MK1 also increased mean arterial pressure, heart rate and body temperature. These effects were prevented by pretreatment with the anti-BDNF antibody whereas the intracerebroventricular administration of BDNF caused changes similar to those of MK1. These findings demonstrate for the first time that activation of MC4R leads to an acute release of BDNF in the hypothalamus. This release is a prerequisite for MC4R-induced effects on appetite, body temperature and cardiovascular function. By contrast, CB1R antagonist-mediated anorexia is independent of the MC4R/BDNF pathway. Overall, these results show that BDNF is an important downstream mediator of the MC4R pathway.
PMID: 18001327 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード