絞り込み

16614

広告

気管支鏡後に胸部X線写真は全例撮影すべき? (日経BP)

呼吸器内科医の皆さんは、気管支鏡を挿入した後に胸部単純X線写真を撮影していますか? 気管支鏡処置の内容によりけりで、生検を行った症例には全例撮影し、観察や洗浄の...

  1. 進行食道癌の2次治療でのペムブロリズマブ...
  2. 放射性ヨウ素内用療法は癌死亡を増やすか?...
  3. 新人ナースの友情 (日経BP)
  4. 癌の遺伝子パネル検査って、保険で行う臨床...

ニュース一覧

Induction of apoptosis by YTX in myoblast cell lines via mitochondrial signalling transduction pathway.

著者 Korsnes MS , Hetland DL , Espenes A , Aune T
Toxicol In Vitro.2006 Dec ; 20(8):1419-26.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

The Norwegian School of Veterinary Science, Food Safety and Infection Biology, Ullevaalsveien 72, P.O. Box 8146 Dep NO-0033 Oslo, Norway. Monica.Suarez@veths.no

スターを付ける スターを付ける     (1,380view , 0users)

Full Text Sources

Miscellaneous

Yessotoxin (YTX) can induce apoptotic events in myoblast L6 and BC3H1 cell lines from rat and mouse, respectively. The present study indicates that apoptosis induced by YTX in these cell lines can occur through activation of the mitochondrial pathway indicating an intracellular response. Terminal events during mitochondrial-mediated apoptosis involve perturbations to mitochondria resulting in loss of mitochondrial membrane potential (DeltaPsi(m)), permeability transition pore (PTP) opening and the release of proapoptotic factors cytochrome c, smac/DIABLO into the cytosol. Results from western blotting, electron and fluorescent microscopy of YTX-treated myoblast cells provided experimental data for evaluation of cytochrome c, smac/DIABLO release and caspase-9 activation. Loss of mitochondrial membrane potential and swelling of mitochondria indicated an active role of mitochondria during the early phase of apoptosis in L6 and BC3H1 cells after YTX exposure. These observations show that YTX targets mitochondria and involve activation of a cascade of events through mitochondrial regulation.
PMID: 16926092 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード