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16643

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A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists.

著者 Perrone MG , Santandrea E , Giorgio E , Bleve L , Scilimati A , Tortorella P
Bioorg Med Chem.2006 Feb 15 ; 14(4):1207-14.
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Enantiomerically pure (R)-2-chloro-1-(pyridin-3-yl)ethanol has been prepared by kinetic resolution performed in the presence of Candida antarctica SP435-L lipase immobilized on a macroporous polyacrylate resin (Novozym 435). It was converted into (R)-1-(pyridin-3-yl)-2-aminoethanol, left-hand side of beta(3)-adrenergic receptor ligands.
PMID: 16216512 [PubMed - indexed for MEDLINE]
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