絞り込み

16640

広告

Oral delivery system of insulin microspheres: effect on relative hypoglycemia of diabetic albino rats.

著者 Senthil Rajan D , Mandal UK , Veeran Gowda K , Bose A , Ganesan M , Pal TK
Boll Chim Farm.2004 Oct ; 143(8):315-8.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Department of Pharmaceutical Technology, Jadavpur University, Kolkata, Westbengal, India.

スターを付ける スターを付ける     (745view , 0users)

Medical

Other Literature Sources

The aim of the present work was to investigate the effectiveness of a dosage form approach for monitoring both the inactivation and the absorption process by targeting insulin delivery to the upper region of small intestine. The dosage form is based on the incorporation of insulin with protease inhibitor and absorption enhancer into polyacrylic polymer Eudragit L-100. Insulin microspheres were prepared by solvent evaporation technique. And also study the effect of these microspheres upon the relative hypoglycemia (RH) effect in white diabetic albino rats has been studied in comparison to that produced after subcutaneous injection of bovine insulin solution. The oral administration of formulation with aprotinin and bile salts gave significant (p< 0.01) hypoglycemia when compared with formulation with insulin alone and with insulin and bile salts. However, the duration, course and the intensity of effect were different for each formulation. It was interesting to observe that the co-administration of aprotinin and bile salts produce prolonged and significant reduction of blood glucose level. A reduction of 4.47-36.81% in plasma glucose levels and RH of about 11.7% relative to subcutaneous injection of soluble insulin solution can be achieved by encapsulation along with protease inhibitor and bile salts.
PMID: 15884295 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード