Synthesis and anticonvulsant activity of some piperazine derivatives.
, Korona R
, Szneler E
Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, Medyczna 9, Kraków, Poland.
Various 1,4-substituted derivatives of piperazine (I-XII) were synthesized and evaluated for their anticonvulsant activity in the maximal electroshock (MES) and subcutaneous pentylenetetrazole (ScMet)--induced seizures and for neurotoxicity (TOX) in the rotorod test in mice and rats. The most promising compounds seem to be 1-[(2,4,6-trimethyl)-phenoxyethyl]-4-(2-hydroxyethyl)-piperazine dihydrochloride (II) and 1,4-bis-[(4-chloro-3-methyl)-phenoxyethyl]-piperazine dihydrochloride (X) which displayed anti-MES activity with their protective index (PI) higher than that for valproate II (rats), X(mice)).
PMID: 15881810 [PubMed - indexed for MEDLINE]