絞り込み

16526

広告

「節電」から「省エネ」へ 阪神間自治体の夏対応 - 神戸新聞

神戸新聞「節電」から「省エネ」へ 阪神間自治体の夏対応神戸新聞関西広域連合が昨夏から、節電も含め温暖化対策として「省エネ」を使用するようになったためで、市の担当...

  1. 「H3」の新型エンジン 燃焼試験を公開 ...
  2. 診断内容共有せず がん患者死亡 横浜市立...
  3. 日本のテレビ番組をミャンマーに 現地で合...
  4. 公開シンポジウム「サプライチェーン全体で...

ニュース一覧

Act1, a negative regulator in CD40- and BAFF-mediated B cell survival.

著者 Qian Y , Qin J , Cui G , Naramura M , Snow EC , Ware CF , Fairchild RL , Omori SA , Rickert RC , Scott M , Kotzin BL , Li X
Immunity.2004 Oct ; 21(4):575-87.
この記事をPubMed上で見るPubMedで表示
この記事をGoogle翻訳上で見る Google翻訳で開く

Department of Immunology, Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.

スターを付ける スターを付ける     (1,492view , 0users)

Full Text Sources

Miscellaneous

Molecular Biology Databases

Other Literature Sources

TNF receptor (TNFR) superfamily members, CD40, and BAFFR play critical roles in B cell survival and differentiation. Genetic deficiency in a novel adaptor molecule, Act1, for CD40 and BAFF results in a dramatic increase in peripheral B cells, which culminates in lymphadenopathy and splenomegaly, hypergammaglobulinemia, and autoantibodies. While the B cell-specific Act1 knockout mice displayed a similar phenotype with less severity, the pathology of the Act1-deficient mice was mostly blocked in CD40-Act1 and BAFF-Act1 double knockout mice. CD40- and BAFF-mediated survival is significantly increased in Act1-deficent B cells, with stronger IkappaB phosphorylation, processing of NF-kappaB2 (p100/p52), and activation of JNK, ERK, and p38 pathways, indicating that Act1 negatively regulates CD40- and BAFF-mediated signaling events. These findings demonstrate that Act1 plays an important role in the homeostasis of B cells by attenuating CD40 and BAFFR signaling.
PMID: 15485634 [PubMed - indexed for MEDLINE]
印刷用ページを開く Endnote用テキストダウンロード