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[Low prevalence of anti-annexin V antibodies in antiphospholipid syndrome with fetal loss].

著者 Siaka C , Lambert M , Caron C , Amiral J , Hachulla E , Hatron PY , Goudemand J
Rev Med Interne.1999 Sep ; 20(9):762-5.
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Laboratoire d'hémostase, hôpital Claude-Huriez, Lille, France.

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Annexin V, a protein with potent anticoagulant activity has a calcium-dependent binding affinity for phospholipids. Annexin V is distributed in many organs, especially in the placenta and endothelium. Various studies have shown that placental annexin V is decreased in women with anti-phospholipid syndrome. It has been suggested that annexin V might be a target of anti-phospholipid antibodies and that the subsequent decrease in annexin V might be associated with obstetrical complications. We investigated the presence of anti-annexin V antibodies in the plasma of women with anti-phospholipid syndrome and obstetrical complications.
PMID: 10522297 [PubMed - indexed for MEDLINE]
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